codon-optimized human cep290 coding dna sequence (cds) Search Results


nrf2  (Proteintech)
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Proteintech nrf2
The expression distribution between CEP290 and <t>Nrf2</t> pathway members in single-cell profiling. ( A ) Co-expression correlation analysis using the TCGA-LIHC RNA-Seq cohort (n=374). ( B ) t-SNE map shows three liver cancer cell classes. Each dot represents one cell. ( C – H ) Profile of target expression (scRNA-Seq) based on the t-SNE plot from .
Nrf2, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The expression distribution between CEP290 and Nrf2 pathway members in single-cell profiling. ( A ) Co-expression correlation analysis using the TCGA-LIHC RNA-Seq cohort (n=374). ( B ) t-SNE map shows three liver cancer cell classes. Each dot represents one cell. ( C – H ) Profile of target expression (scRNA-Seq) based on the t-SNE plot from .

Journal: Aging (Albany NY)

Article Title: Centrosomal protein 290 is a novel prognostic indicator that modulates liver cancer cell ferroptosis via the Nrf2 pathway

doi: 10.18632/aging.203946

Figure Lengend Snippet: The expression distribution between CEP290 and Nrf2 pathway members in single-cell profiling. ( A ) Co-expression correlation analysis using the TCGA-LIHC RNA-Seq cohort (n=374). ( B ) t-SNE map shows three liver cancer cell classes. Each dot represents one cell. ( C – H ) Profile of target expression (scRNA-Seq) based on the t-SNE plot from .

Article Snippet: The following antibodies CEP290 (ab85728, Abcam, USA), Nrf2 , NQO1 , HO-1 (Proteintech, Wuhan, China), FTH1 (Cell Signaling Technology, USA) and β-actin (DianyinBio, Shanghai, China) were used in this study.

Techniques: Expressing, RNA Sequencing

CEP290 knockout inhibits tumor growth in vivo . ( A , B ) The interaction between CEP290 and Nrf2 was analyzed by WB and immunoprecipitation in Hep3B cells. ( C ) Nrf2 expression in nuclear extracts after CEP290 knockout. ( D ) Following CEP290 silencing, the protein expression of Nrf2 and the respective downstream members ( HO-1 , FTH1 and NQO1 ) were detected by WB, and ( E ) the protein levels of CEP290 were quantified. ( F ) Selection of optimal oltipraz dose. ( G ) Gross appearances of tumors. Male nude mice (six weeks old, n = 5 for each group) were subcutaneously injected with Hep3B and CEP290 -KO Hep3B cells (2 × 10 6 ) on the right flank. The mouse tumors were collected 2 weeks after implantation. ( H ) Xenograft tumor sizes were determined in mice bearing tumors. ( I ) A proposed model of the CEP290 / Nrf2 axis activation in HCC. All results are presented as the mean ± SD; ** p < 0.01; *** p < 0.001.

Journal: Aging (Albany NY)

Article Title: Centrosomal protein 290 is a novel prognostic indicator that modulates liver cancer cell ferroptosis via the Nrf2 pathway

doi: 10.18632/aging.203946

Figure Lengend Snippet: CEP290 knockout inhibits tumor growth in vivo . ( A , B ) The interaction between CEP290 and Nrf2 was analyzed by WB and immunoprecipitation in Hep3B cells. ( C ) Nrf2 expression in nuclear extracts after CEP290 knockout. ( D ) Following CEP290 silencing, the protein expression of Nrf2 and the respective downstream members ( HO-1 , FTH1 and NQO1 ) were detected by WB, and ( E ) the protein levels of CEP290 were quantified. ( F ) Selection of optimal oltipraz dose. ( G ) Gross appearances of tumors. Male nude mice (six weeks old, n = 5 for each group) were subcutaneously injected with Hep3B and CEP290 -KO Hep3B cells (2 × 10 6 ) on the right flank. The mouse tumors were collected 2 weeks after implantation. ( H ) Xenograft tumor sizes were determined in mice bearing tumors. ( I ) A proposed model of the CEP290 / Nrf2 axis activation in HCC. All results are presented as the mean ± SD; ** p < 0.01; *** p < 0.001.

Article Snippet: The following antibodies CEP290 (ab85728, Abcam, USA), Nrf2 , NQO1 , HO-1 (Proteintech, Wuhan, China), FTH1 (Cell Signaling Technology, USA) and β-actin (DianyinBio, Shanghai, China) were used in this study.

Techniques: Knock-Out, In Vivo, Immunoprecipitation, Expressing, Selection, Injection, Activation Assay